Race, kidney disease progression, and mortality risk in HIV-infected persons.

Alves TP, Hulgan T, Wu P, Sterling TR, Stinnette SE, Rebeiro PF, Vincz AJ, Bruce M, Ikizler TA
Clin J Am Soc Nephrol. 2010 5 (12): 2269-75

PMID: 20876679 · PMCID: PMC2994089 · DOI:10.2215/CJN.00520110

BACKGROUND AND OBJECTIVES - The burden of HIV-associated chronic kidney disease (CKD) is growing in the United States, partially because of increased HIV-infection rates among African Americans. We determined the prevalence, incidence, and risk of rapid estimated GFR (eGFR) decline, ESRD, and death among HIV-infected (HIV+) African-American and non-African-American individuals cared for at the Comprehensive Care Center in Nashville, Tennessee, from January 1, 1998, through December 31, 2005.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS - Mixed effects, competing risks, and Poisson and Cox regression models were used to assess the risk of rapid eGFR decline (defined as ≥50% decrease in baseline eGFR), CKD5/ESRD, and death. The Chronic Kidney Disease Epidemiology Collaboration equation was used to calculate eGFR. Confounders were adjusted with a propensity score that related patient characteristics to the probability of being African American. Mixed effects models compared the rate of rapid eGFR decline for HIV-infected African Americans and non-African Americans.

RESULTS - There were 2468 HIV-infected individuals in the study: 33% African American; 21% female. Among all patients, HIV-infected African Americans did not have a statistically significant increased risk for rapid eGFR decline compared with non-African Americans. However, African Americans had a significantly higher risk of ESRD and tended toward a higher risk of death.

CONCLUSIONS - HIV-infected African Americans did not have a statistically significant difference in the risk of eGFR decline when compared with HIV-infected non-African Americans. The findings in this study have potential public health significance.

MeSH Terms (14)

Adult African Americans Antiretroviral Therapy, Highly Active Chronic Disease Cohort Studies Disease Progression Female Follow-Up Studies Glomerular Filtration Rate HIV Infections Humans Kidney Diseases Male Risk

Connections (4)

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