Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia.

Orr B, Vanpoucke G, Grace OC, Smith L, Anderson RA, Riddick AC, Franco OE, Hayward SW, Thomson AA
Prostate. 2011 71 (3): 305-17

PMID: 20812209 · PMCID: PMC3045659 · DOI:10.1002/pros.21244

MeSH Terms (18)

Animals Carrier Proteins Cell Differentiation Cytokines Epithelial Cells Female Fibroblasts Humans Male Mesoderm Mice Paracrine Communication Prostate Prostatic Neoplasms Receptors, Androgen RNA, Messenger Testosterone Urethra

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