Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists.

Mandawat A, Fiskus W, Buckley KM, Robbins K, Rao R, Balusu R, Navenot JM, Wang ZX, Ustun C, Chong DG, Atadja P, Fujii N, Peiper SC, Bhalla K
Blood. 2010 116 (24): 5306-15

PMID: 20810927 · DOI:10.1182/blood-2010-05-284414

MeSH Terms (17)

Antineoplastic Combined Chemotherapy Protocols Apoptosis Benzylamines Cyclams Drug Synergism Heterocyclic Compounds Histone Deacetylase Inhibitors Humans Hydroxamic Acids Indoles Leukemia, Myeloid, Acute Panobinostat Peptides, Cyclic Receptors, CXCR4 RNA, Messenger Signal Transduction Tumor Cells, Cultured

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