TGF-beta biology in mammary development and breast cancer.

Moses H, Barcellos-Hoff MH
Cold Spring Harb Perspect Biol. 2011 3 (1): a003277

PMID: 20810549 · PMCID: PMC3003461 · DOI:10.1101/cshperspect.a003277

Transforming growth factor-β1 (TGF-β) was first implicated in mammary epithelial development by Daniel and Silberstein in 1987 and in breast cancer cells and hormone resistance by Lippman and colleagues in 1988. TGF-β is critically important for mammary morphogenesis and secretory function through specific regulation of epithelial proliferation, apoptosis, and extracellular matrix. Differential TGF-β effects on distinct cell types are compounded by regulation at multiple levels and the influence of context on cellular responses. Studies using controlled expression and conditional-deletion mouse models underscore the complexity of TGF-β biology across the cycle of mammary development and differentiation. Early loss of TGF-β growth regulation in breast cancer evolves into fundamental deregulation that mediates cell interactions and phenotypes driving invasive disease. Two outstanding issues are to understand the mechanisms of biological control in situ and the circumstances by which TGF-β regulation is subverted in neoplastic progression.

MeSH Terms (10)

Animals Breast Neoplasms Epithelial Cells Female Humans Mammary Glands, Human Mice Morphogenesis Signal Transduction Transforming Growth Factor beta1

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