Characterization of 1H NMR signal in human cortical bone for magnetic resonance imaging.

Horch RA, Nyman JS, Gochberg DF, Dortch RD, Does MD
Magn Reson Med. 2010 64 (3): 680-7

PMID: 20806375 · PMCID: PMC2933073 · DOI:10.1002/mrm.22459

Recent advancements in MRI have enabled clinical imaging of human cortical bone, providing a potentially powerful new means for assessing bone health with molecular-scale sensitivities unavailable to conventional X-ray-based diagnostics. In human cortical bone, MRI is sensitive to populations of protons ((1)H) partitioned among water and protein sources, which may be differentiated according to intrinsic NMR properties such as chemical shift and transverse and longitudinal relaxation rates. Herein, these NMR properties were assessed in human cortical bone donors from a broad age range, and four distinct (1)H populations were consistently identified and attributed to five microanatomical sources. These findings show that modern human cortical bone MRI contrast will be dominated by collagen-bound water, which can also be exploited to study human cortical bone collagen via magnetization transfer.

2010 Wiley-Liss, Inc.

MeSH Terms (12)

Adult Aged Aged, 80 and over Cadaver Female Femur Humans Magnetic Resonance Spectroscopy Male Middle Aged Protons Young Adult

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