Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.

Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW
J Med Chem. 2010 53 (18): 6706-19

PMID: 20735042 · PMCID: PMC3179181 · DOI:10.1021/jm100814g

MeSH Terms (22)

Allosteric Regulation Animals Antineoplastic Agents Apoptosis Blood Proteins Cell Line Cell Line, Tumor Cell Proliferation Drug Design Drug Screening Assays, Antitumor Humans Isoenzymes Male Microsomes, Liver Naphthalenes Phospholipase D Protein Binding Rats Rats, Sprague-Dawley Spiro Compounds Stereoisomerism Structure-Activity Relationship

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