Molecular imaging by mass spectrometry--looking beyond classical histology.

Schwamborn K, Caprioli RM
Nat Rev Cancer. 2010 10 (9): 639-46

PMID: 20720571 · DOI:10.1038/nrc2917

Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.

MeSH Terms (8)

Animals Drug Discovery Humans Mice Neoplasms Proteome Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Treatment Outcome

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