Follicular B cell trafficking within the spleen actively restricts humoral immune responses.

Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, Joyce S, Thomas JW, Van Kaer L, Sebzda E
Immunity. 2010 33 (2): 254-65

PMID: 20691614 · PMCID: PMC2929658 · DOI:10.1016/j.immuni.2010.07.016

Follicular (FO) and marginal zone (MZ) B cells are maintained in distinct locations within the spleen, but the genetic basis for this separation is still enigmatic. We now report that B cell sequestration requires lineage-specific regulation of migratory receptors by the transcription factor Klf2. Moreover, using gene-targeted mice we show that altered splenic B cell migration confers a significant in vivo gain-of-function phenotype to FO B cells, including the ability to quickly respond to MZ-associated antigens and pathogens in a T cell-dependent manner. This work demonstrates that in wild-type animals, naive FO B cells are actively removed from the MZ, thus restricting their capacity to respond to blood-borne pathogens.

Copyright 2010 Elsevier Inc. All rights reserved.

MeSH Terms (14)

Animals Antigens, CD19 Antigens, T-Independent B-Lymphocytes Bone Marrow Cell Differentiation Cell Movement Cells, Cultured Immunity, Humoral Kruppel-Like Transcription Factors Mice Mice, Knockout Receptors, CCR Spleen

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