Dopaminergic network differences in human impulsivity.

Buckholtz JW, Treadway MT, Cowan RL, Woodward ND, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Shelby ES, Smith CE, Kessler RM, Zald DH
Science. 2010 329 (5991): 532

PMID: 20671181 · PMCID: PMC3161413 · DOI:10.1126/science.1185778

Dopamine (DA) has long been implicated in impulsivity, but the precise mechanisms linking human variability in DA signaling to differences in impulsive traits remain largely unknown. By using a dual-scan positron emission tomography approach in healthy human volunteers with amphetamine and the D2/D3 ligand [18F]fallypride, we found that higher levels of trait impulsivity were predicted by diminished midbrain D2/D3 autoreceptor binding and greater amphetamine-induced DA release in the striatum, which was in turn associated with stimulant craving. Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release.

MeSH Terms (22)

Adolescent Adult Amphetamine-Related Disorders Autoreceptors Benzamides Corpus Striatum Dextroamphetamine Dopamine Female Humans Impulsive Behavior Ligands Male Positron-Emission Tomography Pyrrolidines Receptors, Dopamine D2 Receptors, Dopamine D3 Signal Transduction Substantia Nigra Tegmentum Mesencephali Ventral Tegmental Area Young Adult

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