Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.

Rao R, Nalluri S, Fiskus W, Balusu R, Joshi A, Mudunuru U, Buckley KM, Robbins K, Ustun C, Reuther GW, Bhalla KN
Mol Cancer Ther. 2010 9 (8): 2232-42

PMID: 20663926 · PMCID: PMC3008427 · DOI:10.1158/1535-7163.MCT-10-0336

MeSH Terms (22)

Animals Benzoquinones Bone Marrow Cells Carbazoles Cell Differentiation Cell Line, Tumor Coculture Techniques HSP90 Heat-Shock Proteins Humans Indole Alkaloids Lactams, Macrocyclic Leukemia, Myeloid, Acute Nerve Growth Factor PC12 Cells Phosphorylation Polyubiquitin Proteasome Endopeptidase Complex Rats Receptor, trkA Signal Transduction Stromal Cells Ubiquitination

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