Antiepoetin antibody-related pure red cell aplasia: successful remission with cessation of recombinant erythropoietin alone.

Katagiri D, Shibata M, Katsuki T, Masumoto S, Katsuma A, Minami E, Hoshino T, Inoue T, Tada M, Hinoshita F
Clin Exp Nephrol. 2010 14 (5): 501-5

PMID: 20652821 · DOI:10.1007/s10157-010-0318-8

An elderly patient with pure red cell aplasia (PRCA) with antierythropoietin (anti-EPO) antibodies is described. PRCA due to alloimmunization is a rare and severe complication of recombinant human erythropoietin (rHu-EPO) therapy. Most reported patients with PRCA were cured primarily by immunosuppressive drug therapy. The patient in this case, however, did not want to receive any immunosuppressive drugs. Therefore, rHu-EPO injection was simply discontinued, the severe anemia gradually improved, and the hemoglobin approached normal range. This case is very rare and significant in that there have been few such elderly patients with rHu-EPO-induced PRCA in whom PRCA remission was achieved, with decreasing antibody titers, after cessation of rHu-EPO alone. Further cases are needed to assess how PRCA should be treated in patients with anti-EPO antibodies.

MeSH Terms (9)

Aged, 80 and over Antibodies, Neutralizing Epoetin Alfa Erythropoietin Hematinics Humans Kidney Failure, Chronic Recombinant Proteins Red-Cell Aplasia, Pure

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