Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.

Prichard J, Rothman D, Novotny E, Petroff O, Kuwabara T, Avison M, Howseman A, Hanstock C, Shulman R
Proc Natl Acad Sci U S A. 1991 88 (13): 5829-31

PMID: 2062861 · PMCID: PMC51971 · DOI:10.1073/pnas.88.13.5829

Brain lactate concentration is usually assumed to be stable except when pathologic conditions cause a mismatch between glycolysis and respiration. Using newly developed 1H NMR spectroscopic techniques that allow measurement of lactate in vivo, we detected lactate elevations of 0.3-0.9 mM in human visual cortex during physiologic photic stimulation. The maximum rise appeared in the first few minutes; thereafter lactate concentration declined while stimulation continued. The results are consistent with a transient excess of glycolysis over respiration in the visual cortex, occurring as a normal response to stimulation in the physiologic range.

MeSH Terms (7)

Energy Metabolism Humans Lactates Magnetic Resonance Spectroscopy Vision, Ocular Visual Cortex Visual Perception

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