Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.

McDonald DR, Goldman F, Gomez-Duarte OD, Issekutz AC, Kumararatne DS, Doffinger R, Geha RS
J Allergy Clin Immunol. 2010 126 (2): 332-7, 337.e1-2

PMID: 20621347 · PMCID: PMC2917474 · DOI:10.1016/j.jaci.2010.05.013

BACKGROUND - IL-1 receptor-associated kinase 4 (IRAK-4) is an effector of the Toll-like receptor and IL-1 receptor pathways that plays a critical role in innate immune responses. The role of IRAK-4 in adaptive immune functions in human subjects is incompletely understood.

OBJECTIVE - We sought to evaluate T-cell function in IRAK-4 deficient patients.

METHODS - We compared upregulation of CD25 and CD69 on T cells and production of IL-2, IL-6, and IFN-gamma after stimulation of PBMCs from 4 IRAK-4-deficient patients and healthy control subjects with anti-CD3 and anti-CD28.

RESULTS - Upregulation of CD25 and CD69 on T cells and production of IL-6 and IFN-gamma, but not IL-2, was significantly reduced in IRAK-4-deficient patients.

CONCLUSIONS - IRAK-4-deficient patients have defects in T-cell activation.

Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

MeSH Terms (17)

Adaptive Immunity Antigens, CD Antigens, Differentiation, T-Lymphocyte Case-Control Studies Cytokines Female Genetic Diseases, Inborn Humans Immunologic Deficiency Syndromes Interleukin-1 Receptor-Associated Kinases Interleukin-2 Receptor alpha Subunit Lectins, C-Type Lymphocyte Activation Male Receptors, Antigen, T-Cell T-Lymphocytes Up-Regulation

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