Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer.

Chmielecki J, Peifer M, Jia P, Socci ND, Hutchinson K, Viale A, Zhao Z, Thomas RK, Pao W
Nucleic Acids Res. 2010 38 (20): 6985-96

PMID: 20587502 · PMCID: PMC2978357 · DOI:10.1093/nar/gkq579

MeSH Terms (15)

Amino Acid Motifs Cell Line, Tumor Chromosome Breakpoints Chromosome Mapping Conserved Sequence Cytoskeletal Proteins Humans Mutant Chimeric Proteins Neoplasm Proteins Protein-Tyrosine Kinases Proto-Oncogene Proteins c-ret Receptor, Fibroblast Growth Factor, Type 1 Sequence Analysis, DNA Sequence Analysis, Protein Signal Transduction

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