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The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.

Jin X, Semenova S, Yang L, Ardecky R, Sheffler DJ, Dahl R, Conn PJ, Cosford ND, Markou A
Neuropsychopharmacology. 2010 35 (10): 2021-36

PMID: 20555310 · PMCID: PMC2922422 · DOI:10.1038/npp.2010.82

MeSH Terms (27)

Amino Acids Analysis of Variance Animals Behavior, Animal Biphenyl Compounds Brain Bridged Bicyclo Compounds, Heterocyclic Cell Line, Transformed Cocaine Cues Dopamine Uptake Inhibitors Dose-Response Relationship, Drug Drug Interactions Excitatory Amino Acid Agonists Extinction, Psychological Feeding Behavior Glutamic Acid Humans Indans Male Rats Rats, Wistar Receptors, Metabotropic Glutamate Reinforcement Schedule Reward Self Administration Time Factors

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