The sweet side of HIF.

Haase VH
Kidney Int. 2010 78 (1): 10-3

PMID: 20551925 · PMCID: PMC3789845 · DOI:10.1038/ki.2010.112

Hypoxia-inducible factors (HIFs) are oxygen-sensitive transcription factors that mediate cellular adaptation to hypoxia. Depending on the type of injury, activation of HIF signaling in renal cells may be renoprotective or promote fibrosis. Isoe and colleagues demonstrate that hyperglycemia activates HIF-1 in mesangial cells via carbohydrate response element binding protein (ChREBP), thus providing a novel link between alterations in systemic glucose homeostasis and HIF-regulated gene expression.

MeSH Terms (10)

Animals Gene Expression Regulation Humans Hypoxia Hypoxia-Inducible Factor 1 Mice Oxygen Rats Signal Transduction Transcription Factors

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