Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer.

Miller TW, Hennessy BT, González-Angulo AM, Fox EM, Mills GB, Chen H, Higham C, García-Echeverría C, Shyr Y, Arteaga CL
J Clin Invest. 2010 120 (7): 2406-13

PMID: 20530877 · PMCID: PMC2898598 · DOI:10.1172/JCI41680

MeSH Terms (15)

Apoptosis Breast Neoplasms Estradiol Estrogen Receptor alpha Estrogens Female Hormones Humans Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Phosphorylation Proto-Oncogene Proteins c-akt Receptors, Estrogen Signal Transduction Sirolimus

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