Hypoxic regulation of erythropoiesis and iron metabolism.

Haase VH
Am J Physiol Renal Physiol. 2010 299 (1): F1-13

PMID: 20444740 · PMCID: PMC2904169 · DOI:10.1152/ajprenal.00174.2010

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular and systemic erythropoiesis-promoting hypoxia responses and their potential as a therapeutic target for the treatment of renal anemia are discussed in this review.

MeSH Terms (19)

Anemia Animals Basic Helix-Loop-Helix Transcription Factors Bone Marrow Erythrocytes Erythropoiesis Erythropoietin Gene Expression Regulation Hematinics Homeostasis Humans Hypoxia Iron Kidney Oxygen Polycythemia Procollagen-Proline Dioxygenase Protein Processing, Post-Translational Von Hippel-Lindau Tumor Suppressor Protein

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