Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease.

Ahmed MR, Berthet A, Bychkov E, Porras G, Li Q, Bioulac BH, Carl YT, Bloch B, Kook S, Aubert I, Dovero S, Doudnikoff E, Gurevich VV, Gurevich EV, Bezard E
Sci Transl Med. 2010 2 (28): 28ra28

PMID: 20410529 · PMCID: PMC2933751 · DOI:10.1126/scitranslmed.3000664

MeSH Terms (22)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Antiparkinson Agents Behavior, Animal Dose-Response Relationship, Drug Dyskinesias Endocytosis G-Protein-Coupled Receptor Kinases Gene Knockdown Techniques Genetic Therapy Humans Lentivirus Levodopa Macaca Oxidopamine Parkinsonian Disorders Rats Rats, Sprague-Dawley Receptors, Dopamine D1 Receptors, Dopamine D2 Rotation Signal Transduction

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