Airway PI3K pathway activation is an early and reversible event in lung cancer development.

Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion PP, Lenburg ME, Lam S, Bild AH, Spira A
Sci Transl Med. 2010 2 (26): 26ra25

PMID: 20375364 · PMCID: PMC3694402 · DOI:10.1126/scitranslmed.3000251

MeSH Terms (19)

Adult Aged Bronchi Cohort Studies Enzyme Activation Enzyme Inhibitors Epithelial Cells Gene Expression Regulation, Neoplastic Humans Inositol Lung Neoplasms Middle Aged Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Precancerous Conditions PTEN Phosphohydrolase Pulmonary Disease, Chronic Obstructive Reproducibility of Results Smoking

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