Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning.

Brigman JL, Wright T, Talani G, Prasad-Mulcare S, Jinde S, Seabold GK, Mathur P, Davis MI, Bock R, Gustin RM, Colbran RJ, Alvarez VA, Nakazawa K, Delpire E, Lovinger DM, Holmes A
J Neurosci. 2010 30 (13): 4590-600

PMID: 20357110 · PMCID: PMC2869199 · DOI:10.1523/JNEUROSCI.0640-10.2010

MeSH Terms (12)

Animals CA1 Region, Hippocampal Cerebral Cortex Dendritic Spines Excitatory Postsynaptic Potentials Long-Term Potentiation Long-Term Synaptic Depression Maze Learning Mice Mice, Mutant Strains Patch-Clamp Techniques Receptors, N-Methyl-D-Aspartate

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