Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus.

Xu R, Ekiert DC, Krause JC, Hai R, Crowe JE, Wilson IA
Science. 2010 328 (5976): 357-60

PMID: 20339031 · PMCID: PMC2897825 · DOI:10.1126/science.1186430

The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.

MeSH Terms (20)

Age Factors Amino Acid Sequence Antibodies, Neutralizing Antibodies, Viral Antigenic Variation Cross Reactions Crystallography, X-Ray Disease Outbreaks Epitopes Glycosylation Hemagglutinin Glycoproteins, Influenza Virus Hemagglutinins, Viral Humans Immunoglobulin Fab Fragments Influenza, Human Influenza A Virus, H1N1 Subtype Influenza Vaccines Models, Molecular Molecular Sequence Data Protein Conformation

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