Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state.

Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M
Endocrinology. 2010 151 (5): 2200-10

PMID: 20189998 · DOI:10.1210/en.2009-1153

Neuropeptide W (NPW) is an anorectic peptide produced in the brain. Here, we showed that NPW was present in several hypothalamic nuclei, including the paraventricular hypothalamic nucleus, ventromedial hypothalamic nucleus, lateral hypothalamus, and hypothalamic arcuate nucleus. NPW expression was significantly up-regulated in leptin-deficient ob/ob and leptin receptor-deficient db/db mice. The increase in NPW expression in ob/ob mice was abrogated to control levels after leptin replacement. Leptin induced suppressors of cytokine signaling-3 after phosphorylation of signal transducer and activator of transcription-3 in NPW-expressing neurons. In addition, we demonstrated that NPW reduces feeding via the melanocortin-4-receptor signaling pathway. We also showed that NPW activates proopiomelanocortin and inhibits neuropeptide Y neurons using loose-patch extracellular recording of these neurons identified by promoter-driven green fluorescent protein expression. This study indicates that NPW may play an important role in the regulation of feeding and energy metabolism under the conditions of leptin insufficiency.

MeSH Terms (24)

Animals Anorexia Basal Metabolism Gene Expression Hypothalamus Immunohistochemistry Leptin Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Obese Microscopy, Immunoelectron Neurons Neuropeptides Neuropeptide Y Patch-Clamp Techniques Phosphorylation Rats Rats, Wistar Receptor, Melanocortin, Type 4 Reverse Transcriptase Polymerase Chain Reaction Signal Transduction STAT3 Transcription Factor

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