Risk factors and prevalence of tuberculosis, human immunodeficiency virus, syphilis, hepatitis B virus, and hepatitis C virus among prisoners in Pakistan.

Kazi AM, Shah SA, Jenkins CA, Shepherd BE, Vermund SH
Int J Infect Dis. 2010 14 Suppl 3: e60-6

PMID: 20189863 · PMCID: PMC2905608 · DOI:10.1016/j.ijid.2009.11.012

OBJECTIVE - The objective of this study was to evaluate the burden of sexual- and injection drug use-related infections in male prisoners in Karachi, Pakistan.

METHODS - We administered a structured questionnaire in a cross-sectional survey of 365 randomly selected imprisoned men. We analyzed blood for the human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) by ELISA, and for syphilis by rapid plasma reagin with Treponema pallidum hemagglutination assay confirmation. Subjects with possible tuberculosis (World Health Organization criteria) provided sputum samples for an acid-fast bacillus smear and culture.

RESULTS - The prevalence of tuberculosis was 2.2% (95% CI 0.71-3.8%). Of 357 of the randomly selected prisoners (eight refused to give blood), 2.0% (95% CI 0.6-3.4) were HIV-infected; syphilis was confirmed in 8.9% (95% CI 6.0-11.8%), HBV in 5.9% (95% CI 3.5-8.3%), and HCV in 15.2% (95% CI 11.7-18.8). By self-report, 59.2% had used any illicit drugs, among whom 11.8% (95% CI 8.5-15.0) had injected drugs. The median length of stay in the prison had been 3.2 (range 1-72) months.

CONCLUSIONS - All four infections were prevalent among the prisoners in Pakistan. Prisons are excellent venues for infectious disease screening and intervention given the conditions of poverty and drug addiction. Collaboration with community-based health providers is vital for post-discharge planning.

Copyright © 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

MeSH Terms (20)

Adolescent Adult Aged Aged, 80 and over Cross-Sectional Studies Hepatitis B Hepatitis C Humans Male Middle Aged Multivariate Analysis Pakistan Prevalence Prisoners Risk Factors Sexual Behavior Substance-Related Disorders Syphilis Tuberculosis, Pulmonary Young Adult

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