ABC/XYZ estimates intracerebral hemorrhage volume as a percent of total brain volume in children.

Beslow LA, Ichord RN, Kasner SE, Mullen MT, Licht DJ, Smith SE, Storm PB, Jordan LC, Messé SR
Stroke. 2010 41 (4): 691-4

PMID: 20181678 · PMCID: PMC2930766 · DOI:10.1161/STROKEAHA.109.566430

BACKGROUND AND PURPOSE - Intracerebral hemorrhage volume (ICHV) as a percentage of total brain volume (TBV) is a strong predictor of outcome in childhood intracerebral hemorrhage with ICHV/TBV >2% associated with functional impairment. We aimed to determine whether easily performed approximations of intracerebral hemorrhage and brain volume can accurately and reliably stratify intracerebral hemorrhage by size.

METHODS - CT scans of 18 children with spontaneous intracerebral hemorrhage were independently reviewed by 4 neurologists. ICHV as a proportion of TBV was estimated as ABC/XYZ expressed as a percentage: A= largest axial hemorrhage diameter; B=largest axial diameter perpendicular to A on the same slice; and C=hemorrhage vertical diameter. Similarly, X=largest midline axial diameter of supratentorial brain; Y=largest axial diameter perpendicular to X; and Z=brain vertical diameter. Interrater reliability was measured with intraclass correlation coefficients. ICHV and TBV were measured using computer-assisted manual segmentation tracings to establish criterion validity. Each intracerebral hemorrhage was classified as small (< or = 2% TBV) or large (>2% TBV).

RESULTS - Estimates of ICHV, TBV, and ICHV/TBV using the ABC/XYZ method had outstanding interrater reliability (intraclass correlation coefficient, 0.95 to 0.99). These estimates were highly correlated with volumetric measures (R2=0.77 to 0.96). Sensitivity of the ABC/XYZ method for identifying an ICHV >2% TBV was 100% (95% CI, 89% to 100%). Specificity was 95% (95% CI, 83% to 99%).

CONCLUSIONS - The ABC/XYZ method accurately and reliably estimates ICHV and TBV in children. These values can be used to approximate quickly and easily ICHV as a percentage of TBV, which has important prognostic implications.

MeSH Terms (12)

Adolescent Brain Cerebral Hemorrhage Child Child, Preschool Humans Infant Prognosis Prospective Studies Reproducibility of Results Tomography, X-Ray Computed Treatment Outcome

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