Foamy cell angiosarcoma: a rare and deceptively bland variant of cutaneous angiosarcoma.

Tatsas AD, Keedy VL, Florell SR, Simpson JF, Coffin CM, Kelley MC, Cates JM
J Cutan Pathol. 2010 37 (8): 901-6

PMID: 20175826 · DOI:10.1111/j.1600-0560.2010.01512.x

Cutaneous angiosarcoma can sometimes mimic other benign and malignant lesions, thereby presenting a difficult differential diagnosis. In the two cases of cutaneous angiosarcoma presented herein, extensive foamy cell alteration of tumor cells resembled a reactive xanthogranulomatous process. Foamy cell angiosarcoma is an unusual and deceptively benign morphologic variant of cutaneous angiosarcoma. Critical features for diagnosis include the presence of a deep, permeative, sometimes 'scaffolding' growth pattern and subtle areas of vascular formation.

MeSH Terms (13)

Aged Diagnosis, Differential Foam Cells Forehead Granuloma Head and Neck Neoplasms Hemangiosarcoma Humans Male Shoulder Skin Neoplasms Xanthomatosis Young Adult

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