Action of 6-amino-3-pyridinols as novel antioxidants against free radicals and oxidative stress in solution, plasma, and cultured cells.

Omata Y, Saito Y, Yoshida Y, Jeong BS, Serwa R, Nam TG, Porter NA, Niki E
Free Radic Biol Med. 2010 48 (10): 1358-65

PMID: 20172025 · DOI:10.1016/j.freeradbiomed.2010.02.018

Free radical-mediated lipid peroxidation has been implicated in the pathogenesis of various diseases. Lipid peroxidation products are cytotoxic and they modify proteins and DNA bases, leading eventually to degenerative disorders. Various synthetic antioxidants have been developed and assessed for their capacity to inhibit lipid peroxidation and oxidative stress induced by free radicals. In this study, the capacity of novel 6-amino-2,4,5-trimethyl-3-pyridinols for scavenging peroxyl radicals, inhibiting plasma lipid peroxidation in vitro, and preventing cytotoxicity induced by glutamate, 6-hydroxydopamine, 1-methyl-4-phenylpyridium (MPP(+) ), and hydroperoxyoctadecadienoic acid was assessed. It was found that they exerted higher reactivity toward peroxyl radicals and more potent activity for inhibiting the above oxidative stress than alpha-tocopherol, the most potent natural antioxidant, except against the cytotoxicity induced by MPP(+). These results suggest that the novel 6-amino-3-pyridinols may be potent antioxidants against oxidative stress.

Copyright 2010 Elsevier Inc. All rights reserved.

MeSH Terms (15)

1-Methyl-4-phenylpyridinium alpha-Tocopherol Animals Antioxidants Cytoprotection Fatty Acids, Unsaturated Free Radical Scavengers Glutamic Acid Lipid Peroxidation Oxidation-Reduction Oxidative Stress Oxidopamine PC12 Cells Pyridones Rats

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