Effects of apolipoprotein E-epsilon4 and -epsilon2 in amnestic mild cognitive impairment and dementia in Shanghai: SCOBHI-P.

Borenstein AR, Mortimer JA, Ding Ding , Schellenberg GD, DeCarli C, Qianhua Zhao , Copenhaver C, Qihao Guo , Shugang Chu , Galasko D, Salmon DP, Qi Dai , Yougui Wu , Petersen R, Zhen Hong
Am J Alzheimers Dis Other Demen. 2010 25 (3): 233-8

PMID: 20142627 · PMCID: PMC2872993 · DOI:10.1177/1533317509357736

OBJECTIVE - To determine apolipoprotein E (APOE)-epsilon4 and -epsilon2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China.

METHODS - A total of 34 MCI and 34 dementia cases were recruited from an urban Memory Disorders Clinic and 32 controls were recruited from a residential community served by the clinic. Apolipoprotein E was genotyped using standard methods.

RESULTS - Among controls, frequencies were epsilon2, 0.11; epsilon3, 0.84; and epsilon4, 0.05; among MCI, 0.05, 0.77, and 0.18; and for dementia, 0.02, 0.84, and 0.15, respectively. In education-adjusted models, the odds ratio (OR) = 5.6 for dementia (95% CI = 1.09-29.3) and 4.7 for MCI (95% CI = 0.90-25.2) associated with any epsilon4 allele. The epsilon2 allele was inversely associated with dementia (OR = 0.12, 95% CI = 0.013-0.997) and MCI (OR = 0.38, 95% CI = 0.08-1.61).

CONCLUSIONS - APOE-epsilon4 increases and -epsilon2 decreases the risk of dementia vs normal cognition. Similar trends were observed for amnestic mild cognitive impairment (aMCI).

MeSH Terms (14)

Aged Amnesia Apolipoprotein E2 Apolipoprotein E4 Catchment Area, Health China Cognition Disorders Dementia Female Genotype Humans Male Neuropsychological Tests Severity of Illness Index

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