Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

Huke S, Knollmann BC
J Mol Cell Cardiol. 2010 48 (5): 824-33

PMID: 20097204 · PMCID: PMC2854218 · DOI:10.1016/j.yjmcc.2010.01.011

Increased myofilament Ca(2+) sensitivity is a common attribute of many inherited and acquired cardiomyopathies that are associated with cardiac arrhythmias. Accumulating evidence supports the concept that increased myofilament Ca(2+) sensitivity is an independent risk factor for arrhythmias. This review describes and discusses potential underlying molecular and cellular mechanisms how myofilament Ca(2+) sensitivity affects cardiac excitation and leads to the generation of arrhythmias. Emphasized are downstream effects of increased myofilament Ca(2+) sensitivity: altered Ca(2+) buffering/handling, impaired energy metabolism and increased mechanical stretch, and how they may contribute to arrhythmogenesis.

Copyright (c) 2010 Elsevier Ltd. All rights reserved.

MeSH Terms (9)

Actin Cytoskeleton Animals Arrhythmias, Cardiac Calcium Disease Susceptibility Humans Myocardium Signal Transduction Stress, Mechanical

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