Human papillomavirus is not associated with colorectal cancer in a large international study.

Gornick MC, Castellsague X, Sanchez G, Giordano TJ, Vinco M, Greenson JK, Capella G, Raskin L, Rennert G, Gruber SB, Moreno V
Cancer Causes Control. 2010 21 (5): 737-43

PMID: 20087645 · PMCID: PMC4269349 · DOI:10.1007/s10552-010-9502-0

OBJECTIVE OF THE STUDY - Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer.

METHODS - The GP5+/GP6+ PCR reverse line blot method was used for detection of 37 types of human papillomavirus (HPV) in DNA from paraffin-embedded or frozen tissues from patients with colorectal cancer (n = 279) and normal adjacent tissue (n = 30) in three different study populations, including samples from the United States (n = 73), Israel (n = 106) and Spain (n = 100). Additionally, SPF10 PCR was run on all samples (n = 279) and the Innogenetics INNO-LiPA assay was performed on a subset of samples (n = 15).

RESULTS - All samples were negative for all types of HPV using both the GP5+/GP6+ PCR reverse line blot method and the SPF10 INNO-LiPA method.

CONCLUSIONS - We conclude that HPV types associated with malignant transformation do not meaningfully contribute to adenocarcinoma of the colon.

MeSH Terms (14)

Adenocarcinoma Alphapapillomavirus Case-Control Studies Cell Transformation, Viral Colorectal Neoplasms DNA, Viral Female Humans Israel Male Papillomavirus Infections Polymerase Chain Reaction Spain United States

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