Is the loss of thalamostriatal neurons protective in parkinsonism?

Kusnoor SV, Muly EC, Morgan JI, Deutch AY
Parkinsonism Relat Disord. 2009 15 Suppl 3: S162-6

PMID: 20082981 · PMCID: PMC2900831 · DOI:10.1016/S1353-8020(09)70806-5

Neuronal loss in Parkinson's disease (PD) is more widespread than originally thought. Among the extrastriatal sites in which significant loss of neurons has been reported is the centremedian-parafascicular (CM-PF) complex of the thalamus, which provides one of the three major afferent sources to the striatum. The functional significance of CM-PF loss in PD is unclear. Interestingly, several recent small trials have suggested that deep brain stimulation of the CM-PF improves motor function in PD. We discuss the possible transsynaptic determination of CM-PF loss secondary to nigrostriatal dopamine degeneration, and suggest that expression of the glycoprotein cerebellin1 (Cbln1) in CM-PF neurons may play an important role in striatal synaptic remodeling in parkinsonism.

MeSH Terms (12)

Animals Cell Death Corpus Striatum Dopamine Humans Nerve Degeneration Nerve Tissue Proteins Neural Pathways Parkinson Disease Protein Precursors Synapses Thalamus

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