Widely conserved signaling pathways in the establishment of cell polarity.

McCaffrey LM, Macara IG
Cold Spring Harb Perspect Biol. 2009 1 (2): a001370

PMID: 20066082 · PMCID: PMC2742088 · DOI:10.1101/cshperspect.a001370

How are the asymmetric distributions of proteins, lipids, and RNAs established and maintained in various cell types? Studies from diverse organisms show that Par proteins, GTPases, kinases, and phosphoinositides participate in conserved signaling pathways to establish and maintain cell polarity.

MeSH Terms (11)

Animals Cell Lineage Cell Polarity Drosophila GTP Phosphohydrolases Humans Models, Biological Phenotype Protein Isoforms RNA, Messenger Signal Transduction

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