IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis.

He M, Liang P
J Immunol. 2010 184 (4): 1793-8

PMID: 20061404 · DOI:10.4049/jimmunol.0901829

IL-20 and IL-24 share two different heterodimeric receptors consisting of either IL-20R1 or IL-22R1 and a common IL-20R2 subunit, whereas IL-22 signals through IL-22R1/IL-10R2. However, until now, only IL-20 and IL-22 have been proven to play important roles in vivo in the epidermis where all four receptor subunits are expressed. In this study, we show that IL-24 transgenic mice manifest many similar phenotypes to that of IL-20 and IL-22, including neonatal lethality, epidermal hyperplasia, and abnormality in keratinocyte differentiation. These results support a largely redundant role in epidermal functions for IL-20, IL-22, and IL-24, which seem to be IL-22R1 dependent. Moreover, we show that IL-24 transgenic mice exhibit infiltrating macrophages in the dermis with concomitant increases in MCP-1 production from both keratinocytes in the epidermis and immune infiltrates in the adjacent dermal layer below. Furthermore, we demonstrate that the homodimeric IL-20R2 soluble receptor is a potent blocker for IL-24 and can be used to further dissect the crosstalk among the IL-20 family of cytokines in normal development as well as in autoimmune diseases.

MeSH Terms (22)

Animals Cell Differentiation Cell Line Cell Proliferation Chlorocebus aethiops COS Cells Cricetinae Epidermis Female Genes, Lethal Genes, Overlapping Humans Hyperplasia Immunophenotyping Interleukins Keratinocytes Male Mice Mice, Inbred C57BL Mice, Transgenic Protein Binding Recombinant Fusion Proteins

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