Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps.

Chowdhury G, Calcutt MW, Guengerich FP
J Biol Chem. 2010 285 (11): 8031-44

PMID: 20061389 · PMCID: PMC2832954 · DOI:10.1074/jbc.M109.088039

MeSH Terms (17)

Aldehydes Aryl Hydrocarbon Hydroxylases Binding, Competitive Carbon Radioisotopes Carboxylic Acids Cytochrome P-450 CYP2A6 Deuterium Diethylnitrosamine Dimethylnitrosamine Humans Kinetics Mass Spectrometry Methane Models, Chemical NADP Oxidation-Reduction Substrate Specificity

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