Predictors of outcome in childhood intracerebral hemorrhage: a prospective consecutive cohort study.

Beslow LA, Licht DJ, Smith SE, Storm PB, Heuer GG, Zimmerman RA, Feiler AM, Kasner SE, Ichord RN, Jordan LC
Stroke. 2010 41 (2): 313-8

PMID: 20019325 · PMCID: PMC2821039 · DOI:10.1161/STROKEAHA.109.568071

BACKGROUND AND PURPOSE - The purposes of this study were to describe features of children with intracerebral hemorrhage (ICH) and to determine predictors of short-term outcome in a single-center prospective cohort study.

METHODS - A single-center prospective consecutive cohort study was conducted of spontaneous ICH in children aged 1 to 18 years from January 2006 to June 2008. Exclusion criteria were inciting trauma; intracranial tumor; isolated epidural, subdural, intraventricular, or subarachnoid hemorrhage; hemorrhagic transformation of ischemic stroke; and cerebral sinovenous thrombosis. Hospitalization records were abstracted. Follow-up assessments included outcome scores using the Pediatric Stroke Outcome Measure and King's Outcome Scale for Childhood Head Injury. ICH volumes and total brain volumes were measured by manual tracing.

RESULTS - Twenty-two patients, median age 10.3 years (range, 4.2 to 16.6 years), had presenting symptoms of headache in 77%, focal deficits 50%, altered mental status 50%, and seizures 41%. Vascular malformations caused hemorrhage in 91%. Surgical treatment (hematoma evacuation, lesion embolization or excision) was performed during acute hospitalization in 50%. One patient died acutely. At a median follow-up of 3.5 months (range, 0.3 to 7.5 months), 71% of survivors had neurological deficits; 55% had clinically significant disability. Outcome based on Pediatric Stroke Outcome Measure and King's Outcome Scale for Childhood Head Injury scores was worse in patients with ICH volume >2% of total brain volume (P=0.023) and altered mental status at presentation (P=0.005).

CONCLUSIONS - Spontaneous childhood ICH was due mostly to vascular malformations. Acute surgical intervention was commonly performed. Although death was rare, 71% of survivors had persisting neurological deficits. Larger ICH volume and altered mental status predicted clinically significant disability.

MeSH Terms (22)

Adolescent Brain Brain Damage, Chronic Central Nervous System Vascular Malformations Cerebral Arteries Cerebral Hemorrhage Child Child, Preschool Cohort Studies Comorbidity Disease Progression Female Humans Infant Magnetic Resonance Imaging Male Mortality Neurosurgical Procedures Outcome Assessment, Health Care Prognosis Prospective Studies Severity of Illness Index

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