Publication

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

Bridges TM, Kennedy JP, Cho HP, Breininger ML, Gentry PR, Hopkins CR, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2010 20 (2): 558-62

PMID: 20004578 · PMCID: PMC3177601 · DOI:10.1016/j.bmcl.2009.11.089

MeSH Terms (13)

Allosteric Regulation Animals CHO Cells Cricetinae Cricetulus Drug Design High-Throughput Screening Assays Mice Mice, Knockout Receptor, Muscarinic M1 Receptor, Muscarinic M3 Receptor, Muscarinic M5 Structure-Activity Relationship

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