Should higher vancomycin trough levels be targeted for invasive community-acquired methicillin-resistant Staphylococcus aureus infections in children?

Jimenez-Truque N, Thomsen I, Saye E, Creech CB
Pediatr Infect Dis J. 2010 29 (4): 368-70

PMID: 19935448 · PMCID: PMC3848324 · DOI:10.1097/INF.0b013e3181c52a04

Methicillin-resistant Staphylococcus aureus isolates with vancomycin minimal inhibitory concentrations (MICs) >or=1.5 microg/mL have been associated with poorer clinical outcomes and treatment failures in adults. We evaluated vancomycin MICs in 71 invasive pediatric community-acquired MRSA isolates from 2004 to 2008, using the E-test micromethod and the E-test macro-method. The modal MIC by micromethod was 1.5 microg/mL, and median vancomycin MICs did not increase over time.

MeSH Terms (8)

Anti-Bacterial Agents Child Community-Acquired Infections Humans Methicillin-Resistant Staphylococcus aureus Microbial Sensitivity Tests Staphylococcal Infections Vancomycin

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