The ClC-3 Cl-/H+ antiporter becomes uncoupled at low extracellular pH.

Matsuda JJ, Filali MS, Collins MM, Volk KA, Lamb FS
J Biol Chem. 2010 285 (4): 2569-79

PMID: 19926787 · PMCID: PMC2807314 · DOI:10.1074/jbc.M109.018002

Adenovirus expressing ClC-3 (Ad-ClC-3) induces Cl(-)/H(+) antiport current (I(ClC-3)) in HEK293 cells. The outward rectification and time dependence of I(ClC-3) closely resemble an endogenous HEK293 cell acid-activated Cl(-) current (ICl(acid)) seen at extracellular pH

MeSH Terms (22)

Acids Animals Aorta Cell Compartmentation Cell Line Chloride Channels Chlorides Glutamic Acid Green Fluorescent Proteins Humans Hydrogen Hydrogen-Ion Concentration Kidney Membrane Potentials Mesylates Mice Mice, Mutant Strains Muscle, Smooth, Vascular Mutagenesis Patch-Clamp Techniques RNA, Small Interfering Sulfhydryl Reagents

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