Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.

Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR
J Biol Chem. 2010 285 (3): 1773-80

PMID: 19923211 · PMCID: PMC2804335 · DOI:10.1074/jbc.M109.067470

MeSH Terms (19)

Amino Acid Sequence Benzamides Biocatalysis Crystallography, X-Ray Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System Drug Design Enzyme Inhibitors Humans Ligands Microsomes Models, Molecular Protein Conformation Sterol 14-Demethylase Sterols Substrate Specificity Trypanocidal Agents Trypanosoma brucei brucei Trypanosomiasis, African

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