Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload.

Kaludercic N, Takimoto E, Nagayama T, Feng N, Lai EW, Bedja D, Chen K, Gabrielson KL, Blakely RD, Shih JC, Pacak K, Kass DA, Di Lisa F, Paolocci N
Circ Res. 2010 106 (1): 193-202

PMID: 19910579 · PMCID: PMC2804073 · DOI:10.1161/CIRCRESAHA.109.198366

MeSH Terms (15)

Animals Blood Pressure Cardiomegaly Clorgyline Heart Failure Heart Ventricles Hydrogen Peroxide Mice Mice, Transgenic Monoamine Oxidase Monoamine Oxidase Inhibitors Norepinephrine Oxidative Stress Ventricular Dysfunction, Left Ventricular Remodeling

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