A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.

Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Xiang Z, Watson ML, Christian EP, Doherty JJ, Quirk MC, Snyder DH, Lah JJ, Levey AI, Nicolle MM, Lindsley CW, Conn PJ
J Neurosci. 2009 29 (45): 14271-86

PMID: 19906975 · PMCID: PMC2811323 · DOI:10.1523/JNEUROSCI.3930-09.2009

MeSH Terms (22)

Animals Carboxylic Acids CHO Cells Cholinergic Agents Cricetinae Cricetulus Female Humans In Vitro Techniques Learning Disabilities Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neurons Prefrontal Cortex Quinolones Rats Rats, Sprague-Dawley Receptor, Muscarinic M1 Reversal Learning

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