Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation.

Willey CD, Xiao D, Tu T, Kim KW, Moretti L, Niermann KJ, Tawtawy MN, Quarles CC, Lu B
Int J Radiat Oncol Biol Phys. 2010 77 (5): 1518-26

PMID: 19906497 · PMCID: PMC3688843 · DOI:10.1016/j.ijrobp.2009.06.044

MeSH Terms (19)

Angiogenesis Inhibitors Animals Cell Line, Tumor Combined Modality Therapy Endothelium, Vascular Humans Indoles Intracellular Signaling Peptides and Proteins Lung Neoplasms Mice Neovascularization, Pathologic Protein-Serine-Threonine Kinases Protein Kinase C Protein Kinase Inhibitors Radiation-Sensitizing Agents Radiation Tolerance Sirolimus TOR Serine-Threonine Kinases Xenograft Model Antitumor Assays

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