piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies.

Manuri PV, Wilson MH, Maiti SN, Mi T, Singh H, Olivares S, Dawson MJ, Huls H, Lee DA, Rao PH, Kaminski JM, Nakazawa Y, Gottschalk S, Kebriaei P, Shpall EJ, Champlin RE, Cooper LJ
Hum Gene Ther. 2010 21 (4): 427-37

PMID: 19905893 · PMCID: PMC2938363 · DOI:10.1089/hum.2009.114

MeSH Terms (18)

Antigen-Presenting Cells Antigens, CD19 Cell Line, Tumor Cells, Cultured Coculture Techniques DNA Transposable Elements Electroporation Genetic Therapy Genetic Vectors Glioblastoma Humans K562 Cells Lymphoma, B-Cell Plasmids Receptors, Antigen T-Lymphocytes Transgenes Transposases

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