Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site.

Brown KL, Roginskaya M, Zou Y, Altamirano A, Basu AK, Stone MP
Nucleic Acids Res. 2010 38 (2): 428-40

PMID: 19892827 · PMCID: PMC2811006 · DOI:10.1093/nar/gkp844

MeSH Terms (16)

Base Pairing Base Sequence Binding Sites DNA DNA-Binding Proteins DNA Damage DNA Repair Enzymes Endodeoxyribonucleases Escherichia coli Proteins Humans Models, Molecular Nuclear Magnetic Resonance, Biomolecular Protons Stereoisomerism Thymine Xeroderma Pigmentosum Group A Protein

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