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Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity.

Nikandrova YA, Jiao Y, Baucum AJ, Tavalin SJ, Colbran RJ
J Biol Chem. 2010 285 (2): 923-34

PMID: 19858198 · PMCID: PMC2801293 · DOI:10.1074/jbc.M109.033985

MeSH Terms (21)

Adaptor Proteins, Signal Transducing A Kinase Anchor Proteins Animals Brain Calcineurin Calcium-Calmodulin-Dependent Protein Kinase Type 2 Cell Line Discs Large Homolog 1 Protein Guanylate Kinases Humans Learning Membrane Proteins Mice Multiprotein Complexes Phosphorylation Protein Binding Protein Structure, Tertiary Rats Receptors, AMPA Synapses Synaptic Transmission

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