Regulatory T-cell counter-regulation by innate immunity is a barrier to transplantation tolerance.

Kim JI, Lee MK, Moore DJ, Sonawane SB, Duff PE, O'Connor MR, Yeh H, Lian MM, Deng S, Caton AJ, Markmann JF
Am J Transplant. 2009 9 (12): 2736-44

PMID: 19845585 · PMCID: PMC2796697 · DOI:10.1111/j.1600-6143.2009.02847.x

Innate immune signals foster adaptive immunity through activation of antigen-presenting cells. Recent in vitro evidence suggests that innate signaling may also contribute to immunity by countering the effects of regulatory T cells (T-regs), counter-regulation. We present in vivo evidence using a transgenic skin allograft model that the function of T-regs is lost in the setting of acute skin transplantation but remains intact when grafts were transplanted 1 month prior to allow surgery-induced inflammation to abate. Our findings identify T-reg counter-regulation as a naturally occurring process that accompanies transplantation and an important barrier to T-reg-mediated tolerance. Our finding further highlights the central role of regulatory cell deactivation in the initiation of the immune response.

MeSH Terms (11)

Animals Antigen-Presenting Cells Forkhead Transcription Factors Graft Rejection Immune Tolerance Immunity, Innate Inflammation Mice Mice, Transgenic Skin Transplantation T-Lymphocytes, Regulatory

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