Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.

Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, Piston DW, Huke S, Knollmann BC
J Mol Cell Cardiol. 2010 48 (2): 293-301

PMID: 19835880 · PMCID: PMC2813417 · DOI:10.1016/j.yjmcc.2009.10.005

MeSH Terms (15)

Animals Arrhythmias, Cardiac Calcium Calcium-Binding Proteins Calcium Channel Blockers Calcium Signaling Cell Membrane Permeability Flecainide Humans Mice Myocytes, Cardiac Rats Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum Tetracaine

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