Comment on "The Arabidopsis circadian clock incorporates a cADPR-based feedback loop".

Xu X, Graeff R, Xie Q, Gamble KL, Mori T, Johnson CH
Science. 2009 326 (5950): 230; author reply 230

PMID: 19815758 · PMCID: PMC2934760 · DOI:10.1126/science.1169503

Dodd et al. (Reports, 14 December 2007, p. 1789) reported that the Arabidopsis circadian clock incorporates the signaling molecule cyclic adenosine diphosphate ribose (cADPR). In contrast, we found that there is no rhythm of cADPR levels nor are there any significant effects on the rhythm by cADPR overexpression, thus raising questions about the conclusions of Dodd et al.

MeSH Terms (8)

ADP-ribosyl Cyclase Arabidopsis Calcium Circadian Rhythm Cyclic ADP-Ribose Estradiol Feedback, Physiological Niacinamide

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