Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge.

Brezski RJ, Vafa O, Petrone D, Tam SH, Powers G, Ryan MH, Luongo JL, Oberholtzer A, Knight DM, Jordan RE
Proc Natl Acad Sci U S A. 2009 106 (42): 17864-9

PMID: 19815504 · PMCID: PMC2758810 · DOI:10.1073/pnas.0904174106

MeSH Terms (22)

Animals Antibodies, Monoclonal Antibody-Dependent Cell Cytotoxicity Antibody Affinity Bacterial Proteins Binding Sites Breast Neoplasms Cell Membrane Female Humans Immunoglobulin Fragments Immunoglobulin G In Vitro Techniques Mice Mice, Inbred BALB C Mice, Inbred C57BL Peptide Hydrolases Rats Receptors, IgG Serine Endopeptidases Staphylococcus aureus Streptococcus pyogenes

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