Very late-onset group B Streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency.

Krause JC, Ghandil P, Chrabieh M, Casanova JL, Picard C, Puel A, Creech CB
Clin Infect Dis. 2009 49 (9): 1393-6

PMID: 19814626 · DOI:10.1086/630206

We describe a child with very late-onset group B Streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. Peripheral blood cells obtained from the patient and her brother did not respond to stimulation with either interleukin-1beta or lipopolysaccharide. Sequencing of the interleukin-1 receptor-associated kinase-4 gene revealed 2 novel mutations.

MeSH Terms (9)

Anti-Bacterial Agents Dysentery, Bacillary Female Humans Infant Interleukin-1 Receptor-Associated Kinases Meningitis Sepsis Streptococcus agalactiae

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